Objective: To reduce alcohol and nonmedical use of prescription drugs among Native youth. Methods: Our methods seek population behavior change and our program is based on a combination of qualitative and quantitative data. Our program seek change in important substance use indicators in the individual, family and community domains through the use of logic models. Youth and families remain engaged in our program by 1) participation in community-based activities, 2) culture classes, 3) social media, 4) school involvement, and 5) youth led Councils. Evaluation was conducted for process and outcome. Results: Evaluations of Native populations show significant reductions in alcohol and Rx use. In addition, resiliency and other protective factors increased for program participants. Program participation was excellent for both youth and adults. Tribal government contributed additional funding. Conclusions: Culturally based prevention programs are effective in reducing alcohol and nonmedical use of prescription drugs among Native youth.
Learning Objectives:

A Culturally appropriate substance abuse prevention program is capable of producing significant reductions in monthly alcohol and nonmedical use of prescription drugs over a two-year period among high disparity populations.

Programs that reinforce American Indian youth’s Tribal culture are popular among youth and their families.

Collaborative efforts among multiple stakeholders can result in substantial substance use reductions in non-reservation American Indian youth.

Successful Native substance abuse prevention programs are youth driven and youth focused.